Furosemide should not be administered with NSAIDs because latter (AIIMS Nov 2012)
|A||Prevent platelet aggregation|
|B||Inhibit prostacyclin synthesis|
|C||Decrease sodium reabsorption|
|D||Increase the secretion of furosemide in urine|
a. NSAIDs blunt the diuretic action of furosemide because loop diuretics act partly by secretion of PGI2.
b. It causes renal vasodilation resulting in increased renal blood flow and more filtration of sodium. NSAIDs decrease diuretic action by inhibiting the production of prostacyclins.