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Indian childhood cirrhosis

  1. Onset around first year of life (6 months-4 yrs) Q
  2. Progressive distension of the abdomen marked irritability, unexplained irregular low grade pyrexia
  3. A firm hepatomegaly with sharp leafy margin, Q splenomegaly and progressive liver cell failure Q.
  4. Microscopic changes includes a marked hepatocele damage manifesting as degenerative changes in the cytoplasm.                                                
  5. Clumps of eosinophilic hyaline (Mallory's hyaline) Q is observed in about 15 %of the hepatocytes.
  6. Develops cirrhosis and hepatocellular Q failure.

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