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Lactose intolerance

  1. Intestinal disaccharidases are located in the brush border of epithelial cells of small intestinal mucosa.
  2. Lactase def causes lactose intolerance -primary or secondary
  3. Fermentation of unabsorbed sugar leads to gaseous-distension and frothy character of loose stools.


  1. Presence of more than 1/2% of reducing substances in the fresh stool Q
  2. Acidic stool (pH below 5.5) Q
  3. Breath H2 excretion of more than 11 parts per million Q following a loading dose of lactose

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