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  1. It is fluorinated methyl ethyl ether. It is an isomer of enflurane.
  2. Physical Properties
    1. Colourless
    2. Pungent ethereal odor so induction is not smooth
    3. Non inflammable, non explosive
    4. Vapour pressure similar to halothane (240 mm Hg.).
  3. Anesthetic Properties
    1. Agent with moderate potency (MAC 1.15) and with moderate induction and recovery time (B/G coefficient 1.38).
    2. Not a good analgesic.
    3. Muscle relaxation is moderate. 
  4. Systemic Effects
    1. Cardiovascular System: Hypotension is maximum with isoflurane (It is the inhalational agent of choice for controlled hypotension).
      1. Isoflurane’ s cardiac stability makes it the agent of choice for cardiac patients (except myocardial ischemia).
      2. With isoflurane, the cardiac rhythm is stable as it does not sensitize the heart to catecholamines.
      3. Isoflurane exhibits a phenomenon called coronary steal phenomenon
    2. Cerebral: Rise in intracranial pressure is minimum with isoflurane among inhalational agents and this rise can be reversed with hyperventilation. It also decreases brain’s oxygen consumption. These properties makes isoflurane as agent of choice for neurosurgical procedures.
  5. Indications
    It is agent of choice for cardiac patients and neurosurgery.
    1. NOTE: Isoflurane does not sensitise the heart to adrenergic arrhythmias (cf. halothane) and causes minimal alteration of cardiovascular status.
    2. Coronary circulation is maintained with isoflurane and is thus safer in patients with myocardial ischemia. (MCQ)
    3. Isoflurane does not provoke seizures and is preferred for neurosurgery. (MCQ)

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