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Revision Points

  1. All causes decrease in B.P. & H.R. except isoflurane (causes­ increase H.R.)
  2. Most cardio stable-Isoflurane
  3. All causes decrease in T.V. & R.R.
  4. All causes decrease C.B.F. & I.C.P. (max with enflurane)
  5. All are antiepileptic except enflurane causes seizure
  6. Renal & hepatic blood flow is decreased.
  7. All new inhalational agent have potential risk of causing Malignant hyperthermia (But Most notorious is succinylcholine)
  8. Isoflurane is an isomer of enflurane
  9. Isoflurane causes coronary steal syndrome
  10. No C/I other than Malignant .Hyperthermia
  11. Desflurane boils at room temp-special vaporizer
  12. V. low solubility, high vapor pressure and ultrashort duration
  13. Pungent and airway irritant- salivation, breath holding, coughing, laryngospasm-less suitable for Pediatrics
  14. Carbon mono oxide. Poisoning with soda lime-prevented by use of Ca(OH)2
  15. Sevoflurane-
    1. non pungent and rapidly acting-single breath indication with 4-8%. 
    2. Ideal for induction in pediatrics patients.
    3. Faster emergence-delirium in Paediatric patient-T/t – 1.0/2.0 ug/kg of fentanyl.
  16. Factors Responsible For Depth of Anesthesia:
    1. Solubility of anaesthetic agent in blood
    2. Alveolar blood flow
    3. Partial pressure difference with alveolar gas and venous blood.
    4. Ventilation
    5. Concentration of Gas, - Second Gas effect
    6. Fresh Gas Flow rate, - Breathing circuit volume, second gas effect.
  17. Minimum Alveolar Concentration
    Alveolar Concentration of an inhaled anesthetic that prevents movement in 50% of patients in response to a standard stimulus.

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