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Coagulase Negative Staphylococci (CNS)

  1. Part of the normal flora of the skin.
  2. About 33 species are recognized, S. epidermidis accounts for 75% of clinical isolates.
  3. CNS are opportunistic pathogens causing infections in debilitated or immunocompromised patients   and patients fitted with implants & prosthetic devices.
  4. Morphologically similar to S. aureus & method of isolation are the same
  5. They can be distinguished from S. aureus by failure to coagulate plasma and by lack of clumping factor & deoxyribonuclease.
  6. Staphylococcus epidermidis:
    a.  infections due to this organism are predominantly hospital acquired.
    b.  Associated with catheterization, cerebrospinal fluid shunts, intravascular lines, cardiac prosthetic valves, artificial joints.
    c.   Infections include endocarditis, bacterimia, osteomyelitis, peritonitis, wound infections.
    d.  Many strains produce large amount of polysaccharide slime.
    e.  It is thought to play an important role in adherence of these organisms to surfaces leading to biofilm formation.
  7. Staphylococcus saprophyticus: Important cause of acute urinary tract infection in young healthy sexually active women.

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