Diseases & National Health Programme
HPV vaccine is (DNB Dec 11)
|D||Bivalent & Quadrivalent|
Ref: website of Centres for Disease Control & Prevention, Atlanta Ref: Park 22nd edition; Pg: 216 (Table-41)
1. Both bivalent ( against HPV types 16 & 18) and quadrivalent ( against HPV types 16, 18, 6 & 11) HPV vaccines are available in the market for use and a new nine – valent vaccine is under trial.
2. A new vaccine against nine of the most harmful strains of human papillomavirus (HPV) is under study at the Medical College of Georgia.
3. The vaccine, called nine-valent, is being compared with Gardasil, a quadrivalent vaccine already in the market that works against the two most deadly HPV types. Gardasil, approved by the U.S. Food and Drug Administration in 2006, protects against HPV types 16 and 18, which cause about 70% of HPV-related cervical cancer cases, and types 6 and 11, which cause about 90% of genital wart cases.
4. The new drug could prevent infection from those four types and five other cancer-causing types. Like Gardasil, the new vaccine contains proteins that form virus-like particles that assemble into a hollow sphere resembling HPV's protective coating. Since the sphere lacks the actual viral DNA on the inside, it cannot cause HPV, but the body is tricked into making antibodies to protect against the real thing.