High dose methotrexate is given in: (LQ)
a. Drugs effective in osteosarcoma are: doxorubicin, ifosfamide, cisplatin, and high-dose methotrexate with leucovorin.
b. The various combinations of these agents that have been used have all been equally successful. Osteosarcoma is radioresistant; radiation therapy has no role in the routine management.