Hypersensitive vasculitis involves (AIIMS May 2010)
|C||Post capillary venules|
Cutaneous vasculitisis defined as inflammation of the blood vessels of the dermis.
1. Histopathologic feature is the presence of vasculitis of small vessels.
2. Postcapillaryvenules are the most commonly involved vessels;
3. Capillaries and arterioles may be involved less frequently.
4. This vasculitis is characterized by a leukocytoclasis, It refers to the nuclear debris remaining from the neutrophils that have infiltrated in and around the vessels during the acute stages.
5. In the subacute or chronic stages, mononuclear cells predominate; in certain subgroups, eosinophilic infiltration is seen.
6. Erythrocytes often extravasate from the involved vessels, leading to palpable purpura.
Clinical and Laboratory Manifestations
1. The hallmark of idiopathic cutaneous vasculitis is the predominance of skin involvement.
2. Skin lesions may appear typically as palpable purpura;
The diagnosis by the demonstration of vasculitis on biopsy.
1. Precipitating factor in the cutaneous vasculitis
2. Glucocorticoids are often used in the treatment of idiopathic cutaneous vasculitis.
3. Methotrexate and azathioprine