Hypomagnesemia is caused by (LQ)
a. Furosemide is a sulphanilamide derivative and is most commonly used diuretic. It impairs the electronegative potential of the tubule cells at distal convoluted tubules and hence can reduce absorption of both calcium and magnesium.
b. Digoxin is an inotropic drug and increases cardiac output by inhibiting the membrane bound cardiac enzyme called Na+K+ ATPAse. The drug has diuretic activity but it does not per se cause reduced calcium or magnesium excretion. However, this action helps in clearing salt and water of CHF patients.
c. Aminoglycosides are narrow therapeutic index drugs with ability to block protein synthesis in bacteria. The drugs are nephrotoxic and potassium levels can increase.
d. Cisplatin is a complex plantin compound and has significant nephrotoxicity that can involve renal tubular acidosis and proteinuria. The drug can also cause hyperkalemia.
Extra edge points about causes of hypomagnesemia