Immune complexes are removed from blood by;
a. Tissues macrophages arise by migration of monocytes from the circulation.
b. Common locations of tissue macrophages - are lymph node, spleen, BM, perivascular connective tissue, serous cavities such as peritoneum, pleura, skin connective tissue, lung (Alveolar macrophages), Liver (kupffer cells) bone (osteoclast), CNS (microglia) and synovium (type A lining cell)
c. Monocytes - macrophages mediate effector functions such as destruction of antibody coated bacteria, tumor cells, or even normal hematopietic cells in certain types of antoimmune cytopenias.
- B-cells →
a. Mediate humoral immunity
b. B-cells differentiate into plasma cells and memory B cells. Plasma cells secretes immunoglobulin
- Basophils → release histamine