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Central Nervous System

2 out of 4

In substantianigra, the major neurotransmitter is:

A Dopaminergic
B Acetylcholine

C Noradrenaline

Ans. A Dopaminergic
  1. There is a system of dopaminergic neurons in nigrostriatal dopaminergic system with cell bodies in substantianigra and axon endings in caudate nucleus Q.
  2. In Parkinson’s disease there is loss of dopaminergic cells in the substantianigraQwhich leads to striatal dopamine depletion.
  3. As DOPAMINE activates excitatory Dl receptors in the direct pathway and represses inhibitory D2 receptors in the indirect pathway, this depletion leads to decreased activity of the direct pathway and increased activity of the indirect pathway.