Initial mechanism of action of intra-tympanic gentamicin microwick catherter inserted into inner ear in treatment of menier's disease: [AIIMS Nov. 2010]
|A||Damage outer hair cell|
|B||Binds to hair cell Na+-K' ATPAse channel|
|C||Acts on melanoreceptors of outer hair cell|
|D||Bind to Mg2+ channel|
Intratympanic Gentamicin Therapy
a. Gentamicin is mainly vestibulotoxic.
b. It has been used in daily or biweekly injection into the middle ear.
c. Drug is absorbed through round window and causes destruction of vestibular labyrinth.
d. Total control of vertigo spells has been reported in 60-80% of patients with some relief from symptoms in others.
e. Hearing loss, sometimes severe and profound, has been reported in 4 to 30% of patients treated with mode of therapy.