Ketoacidosis without glycosuria is seen in
|B||Renal tubular acidosis|
Metabolism in starvation : → three stages (Glucagon/Insulin Ratio )
a. 1st stage →
i. Initially energy from blood glucose and stored glycogen → it cannot last long
ii. Then glucose synthesized by gluconeogenesis (Insulin deficiency and glucagon excess
iii. responsible for this) this initial stage lasts for not more than 2 to 3 day is.
iv. Blood sugar falls (40-60 mg%) [ <40mg% is called Hypoglycemia -
b. 2nd Stage →
i. 80-90%- → of energy requirement will be derived from fats and the remainder 10-20% from
ii. This stage last> 2 weeks.
iii. Since due to excess of glucagon and deficiency of Insulin — Activates the Hormone sensitive
iv. lipase →ed Lipolysis →β-oxidation of FFA→Ketone formation (Ketogenesis
c. 3rd stage → Energy obtained from protein break down. This stage last for less than 1 weak; now, we are clear, from above, during prolong starvation. There is ketogenesis and blood glucose level is maintained near normal, therefore no glycosuria (not hyperglycemia).