Coupon Accepted Successfully!


Chronic Glomerulonephritis


Chronic glomerulonephritis is best considered a pool of endstage glomerular disease fed by a number of streams of specific types of glomerulonephritis.

Figure :
Primary glomerular diseases leading to chronic glomerulonephritis (GN). The thickness of the arrows reflects the approximate proportion of patients in each group who progress to chronic glomerulonephritis: poststreptococcal (1% to 2%); rapidly progressive (crescentic) (90%), membranous (30% to 50%), focal glomerulosclerosis (50% to 80%), membranoproliferative glomerulonephritis (50%), IgA nephropathy (30% to 50%).





  1. The kidneys are symmetrically contracted and have diffusely granular, cortical surfaces.
  2. On section, the cortex is thinned, and there is an increase in peripelvic fat. There eventually ensure hyaline obliteration of glomeruli, transforming them into acellular eosinophilic masses.
  3. The hyaline represents a combination of trapped plasma proteins, increased mesangial matrix, basement membrane like material and collagen.
  4. Because hypertension is an accompaniment of chronic glomerulonephritis, arterial and arteriolar sclerosis may be conspicuous.
  5. Marked atrophy of associated tubules, irregular interstitial fibrosis, an mononuclear leukocytic infiltration of the interstitium also occurs. 


Test Your Skills Now!
Take a Quiz now
Reviewer Name