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Histiocytosis X

  1. Histiocytosis X - The most common childhood histiocytosis is the histiocytosis X or Langerhans cell histiocytosis (LCH)
  1. The most common involvement is of the skeleton (80%), Bone lesions can be single or multiple.
  2. The most common sites are skull bones, long bones, spinal vertebrae, mastoid and mandible .
  3. Bony lesions can be painless or present with pain and local swelling
  4. Clinical manifestations includes vertebral collapse and spinal compressions, pathological fracture in long bones, seborrheic skin rash is scalp area and back (58%) lymphadenopathy (33%), hepatosplenomegaly (20%) parenchymal infiltration of lungs (15 %)
  5. Others, exophthalmos, growth retardation, anemia, and thrombocytopenia

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