Mechanism of action of spermicide is:
|A||Vaginal enzyme alteration|
|B||Disrupting cell membrane and motility|
|C||Inhibit glucose transport enzyme|
|D||Activating acrosome enzyme|
Disrupting cell membrane and motility
a. The active chemicals in vaginal spermicides interact with the lipoproteins of the cell membrane to permanently disrupt the cell membranes of spermatozoa, resulting in severe damage to the acrosome, neck, midpiece, and tail of the sperm and rapid, irreversible loss of function and motility within the vagina and viability.
b. Cell permeability increases and the leaking of cellular components occur.