Medullary cancer of the breast
|A||Is associated with BRCA-2 gene|
|B||Often has enlarged lymph nodes in the axilla at presentation|
|C||Has a worse prognosis than invasive ductal carcinoma.|
|D||Is rarely associated with ductal carcinoma in situ.|
(Silverbergh’s Surgical Pathology ;4th edition;page no 473-474 )
a. Medullary carcinoma breast is a special type breast cancer, account for 5-7%% of all invasive breast cancers.
b. Patients usually present at a relatively younger age.
c. The mean age at presentation is in 5th and early 6th decade.
d. The majority of the patient presents with large palpable mass.
e. Association of BRCA-1 is found in hereditary cancers with breast cancer.
f. P53 mutations are found in majority of the cases.
g. Bilaterality is reported in 20% of cases.
h. Approximately 50% of these cancer are associated with DCIS, which is characteristically present at the periphery of the cancer
i. Estrogen receptor positivity is seen in0-33% of the cases.
j. Progesterone positivity is seen in 0-36% of the cases.
k. Because of the intense lymphocyte response associated with the cancer, benign or hyperplasic enlargement of the lymph nodes of the axilla occur.
l. Medullary carcinoma has better prognosis in comparasion to the usual ductal carcinomas.
m. On histopathology lymphocytes are seen intervening between the malignant cells.