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4 out of 7

Prediction rule applies to? (PNQ)

A Extrinsic allergic alveolitis


C Aspergilloma

D All of the above

Ans. A

Extrinsic allergic alveolitis

Extrinsic allergic alveolitis (hypersensitivity pneumonitis) is caused by sensitivity to Aspergillus clavatus (malt worker's lung'Q). It is an inflammatory disorder of lungs involving alveolar walls & terminal airways that is induced in a susceptible host by repeated inhalation.

Prediction rule applies to hypersensitivity pneumonitis. (Ref. Hari-18th ed., Pg- 2118)

1). Exposure to known antigen.

2). Presence of positive antibody to exposed antigen.

3). Recurrent symptoms

4). Inspiratory crackles

5). Symptoms occur after 4 to 8 hrs after exposure.

6). Weight loss.

Diagnosis is based on a history of exposure and presence of serum precipitins to A. clavatus.

Pulmonary fibrosis Q may occur if untreated.

Extra Edge: Other fungal infections Candida and Cryptococcus may cause pneumonia in the immunosuppressed.

Coccidiomycoses: It causes desert rheumatism

Histoplasmosis: It CXR finding resemble like miliary TB.