60 out of 75
Presence of food might be expected to interfere with drug absorption by slowing gastric emptying or by altering the degree of ionisation of the drug in the stomach. Which of the following statements is not correct example: (AIPG 2010)
|A||Absorption of digoxin is delayed by the presence of food|
|B||Concurrent food intake may severely reduce the rate of absorption of phenytoin|
|C||Presence of food enhances the absorption of hydrochlorothiazide|
|D||Antimalarial drug halofantrine is more extensively absorbed if taken with food|
Ans. B Concurrent food intake may severely reduce the rate of absorption of phenytoin
- Presence of food in stomach delays absorption of digoxin as well as digitoxin.
- Oral absorption of halofantrine is variable and is enhanced with food but because of toxicity concerns, it should however not be taken with meals.
- Food ingested has not been found to affect the absorption of hydrochlorothiazide.
- Absorption of phenytoin by oral route is slow, mainly because of its poor oral solubility. We could not find any reference of the effect of food on phenytoin absorption