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Disorders of Renal Tubular Transport

Disorders of tubular function involve single or multiple transport mechanisms in the presence of normal glomerular function. These may be congenital or acquired. The important conditions include renal glucosuria, renal tubular acidosis, Fanconi syndrome, nephrogenic diabetes insipidus and cystinuria.


Features suggesting renal tubular disorder

  1. Growth retardation, failure to thrive
  2. Delayed motor milestones
  3. Polyuria, polydipsia
  4. Recurrent episodes of unexplained fever, vomiting, dehydration; episodic weakness
  5. Rickets, bone pains
  6. Constipation
  7. Craving for salt and savory foods
  8. Renal, ureteric calculi

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