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Contraindications To Surgery

  1. Cardiopulmonary insufficiency, Peripheral and cerebrovascular disease
  2. Active infection
  3. Morbid obesity
  4. Tobacco abuse
  5. Hepatic insufficiency
  6. Other factors that increase the risk associated with a major surgical procedure 
  1. Contraindications to immunosuppression
    1. Infection and malignancy are the primary medical conditions.
    2. Acute infections should be fully resolved at time of transplantation.
    3. HIV currently is an absolute contraindication in most programs.

Type of Malignancy


Breast, colorectal cancer, melanoma, diffuse bladder carcinoma, and non-in situ ovarian cancer

5 years

In situ uterine carcinoma, some renal tumors (clear cell, Wilms', urothelioma), basal or Squamous cell skin carcinoma.

2 years

isolated nodules of Prostatic carcinoma and focal bladder carcinoma

1 year

  1. Other relative contraindications
    1. The risk of recurrent disease is not a contraindication to renal transplantation. Glomerulonephritides (eg, mesangiocapillary glomerulonephritis type 1, IgA nephropathy).
    2. Focal and segmental glomerulosclerosis is associated with a highly variable rate of recurrence in the first  allograft. Q
    3. Nearly all patients with diabetes will show histologic evidence of diabetic nephropathy within 4 years.
    4. Increasingly, the treatment of choice for patients with type 1 diabetes and renal failure is combined kidney and pancreas transplantation or pancreas transplantation after kidney transplantation.
    5. At present, pancreas graft survival is slightly worse in "pancreas after kidney" transplants
    6. The treatment of oxalosis is controversial; some studies favor intensive dialysis followed by combined liver and kidney transplantation.
    7. Hemolytic uremic syndrome may recur following transplantation in response to cyclosporine-based or Utacrolimus-based immunosuppression. Q

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