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Skin autografting in India during the sixth century BCE.

  1. Gaspare Tagliacozzi’s (1545-1599) text on the restoration of the nose, lips, and ears.
  2. In 1906, Mathieu Jaboulay carried out the first attempts at human kidney transplantation.
  3. Corneal and skin transplant developed during 2nd half of 19th century.
  4. Jaboulay used pig and goat kidneys anastomosed to blood vessels of the arm of patients with chronic renal failure, which functioned for approximately 1 hour.
  5. In 1911, Hammond and Sutton of Philadelphia performed the first human-to-human kidney transplant with transient success.
  6. Alexis Carrel, improved the methods of vascular anastomosis and introduced cooling as a method of organ preservation in his work in Chicago. Q
  7. Later, Carrel found that he could successfully autograft dog kidneys; unfortunately, allografts invariably failed. Carrel suggested that "the principle of immunity" might explain this observation.
  8. In 1942, Gibson and Peter Medawar, in their early experience with skin allografts in the treatment of burns sustained in World War II, noted that the second set of grafts from 1 donor is destroyed much faster than the first.
  9. Surgeon Joseph Murray performed first successful human transplant in 1954 between identical twin brothers. Q 

Indications And Contraindication


Chronic renal failure: Renal transplantation is the treatment of choice for patients with chronic renal failure from most causes.
Causes: DiabetesQ – 31%, Chronic glomerulonephritis – 28%, Polycystic kidney disease – 12%, Nephrosclerosis (hypertensive) – 9%, Systemic lupus erythematosus (SLE) – 3%, Interstitial nephritis – 3%
Renal tumors - Renal tumors (eg, Wilms tumor in children, renal cell carcinoma in adults) can be treated with transplantation.

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