Diseases & National Health Programme
Risk factors for coronary artery disease (CAD) include all except: (AIIMS May 09)
|C||Increased homocysteine levels|
Although the precise pathogenesis of CAD is unclear, the risk factors are well known: high blood levels of low density lipoprotein cholesterol (LDL-C) and lipoprotein a low blood levels of high density lipoprotein cholesterol (HDL-C) and serum vitamin E, and poor physical fitness. Homocysteine has recently been identified as a risk factor for coronary, peripheral, and cerebral vascular disease. Patients with homocystinuria, have plasma homocysteine levels 10 to 20 times above normal (hyperhomocysteinemia) and accelerated, premature vascular disease. Homocysteine has a direct toxic effect on endothelium and promotes thrombosis and oxidation of LDL.