The dose of which of the following cephalosporins is not to be decreased in kidney failure?
Ceftriaxone is a short acting cephalosporin and is the drug of choice for 5 conditions:
A. Typhoid fever
C. Resistant pneumococcal infections
D. Gonorohea and H influenza
The drug is totally eliminated by bile and undergoes supersaturation in bile. Therefore, it can produce gall stones. Though both cefoperazone and ceftriaoxone are eliminated by bile; but excretion of cefoperazone is totally eliminated by bile. Ceftrixone is eliminated by 2/3 in bile and 1/3 by renal route. Cefoperazone is an antipseudomonal drug and produces thrombocytopenia as a side effect (BG Katzung, Basic and Clinical Pharmacology; 10th Edition’ 2007, pp-737).