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2 out of 5

The enzyme required for the generation of the ammonium ion in the kidney is:

A Glutamatedehydrogenase

B Glutamateaspartatetransaminase

C Glutaminase

D Glutamate carboxylase

Ans. C Glutaminase

Several reaction in the renal tubular cells produce NH4+. NH4+ is in equilibrium with NH3+ H+ in the cells. The principal reaction producing NH In cells is conversion of glutamine to glutamate and this reaction is catalyzed by the enzyme glutaminase, which is abundant in the renal tubular cells