The following is not a feature of Alzheimer's disease: (AIPG 09)
|B||Senile (neuritic) plaques|
Most common cause of dementia in the elderly.
Dementia – It is a syndrome of acquired global or multifocal impairment of cognitive function involving decline in intellect, memory or personality in the presence of normal consciousness.
Pathogenesis – Risk factors –
1). Old age
2). Low education
3). Positive family history
4). Female sex
5). Past h/o head trauma with concussion
6). Aluminium, Mercury Toxicity
7). Viruses, Prion
8). Genetic factors – Down’s syndrome, APP gene on chromosome 21
Presenilis – 1 gene on chromosome 14
Presenilis – 2 gene on chromosome 1
Apo E 4 gene on chromosome 19(single most important biological marker)
Apo E 2 gene on chromosome 14(protective for Alzheimer’s)
Extra Edge: Smoking is not a cause of AD
Use of NSAID is associated with decrease risk. Q
Extra Edge: Hippocampus
1). It belongs to the limbic system and plays important roles in the consolidation of information from short-term memory to long-term memory (LQ 2012) and spatial navigation.
2). It is located in the medial temporal lobe.
3). It contains two main interlocking parts: Ammon's horn and the dentate gyrus.
4). In Alzheimer's disease, the hippocampus is one of the first regions of the brain to suffer damage; memory problems and disorientation appear among the first symptoms.
5). Damage to the hippocampus can also result from hypoxia, encephalitis, or medial temporal lobe epilepsy.
6). People with extensive, bilateral hippocampal damage have anterograde amnesia—the inability to form or retain new memories.