Topical MITOMYCIN-C is used in: (DNB Dec 2009)
|A||Sturge weber syndrome|
|B||Urinary bladder cancer|
|D||Skull base osteomyelitis|
a. Mitomycin is an anti-tumor antibiotic with alkylating agent like property. It is used in superficial cancer of urinary bladder.
b. The drug has radiomimetic effects, and also sensitizes hypoxic tumor cells to the effects of hypoxia. Hemolytic uraemic syndrome is a known complication of mitomycin.
c. The drug also produces bone marrow depression. The drug of choice for superficial cancer of urinary bladder is BCG given intravesically.