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  1. Atopic Triad:
    The term ‘atopy’ was coined by Perry, as quoted by Coca & Cooke, to describe this triad of atopic eczema, allergic rhinitis and asthma.
  2. Beh|et’s Syndrome:
    Beh|et’s syndrome is a chronic, multisystem disorder characterised by the association of recurrent aphthous stomatitis with recurrent genital ulceration and eye disease (especially iridocyclitis and retinal vasculitis). Other manifestations include optic atrophy, meningoencephalitis, pustules, erythema nodosum, positive pathergy, proteinuria and haematuria, thrombophlebitis, aneurysms, arthralgias.
  3. Graves’ Disease (Diamond’s Triad):
    Graves’ disease is an autoimmune disorder in which there is a high incidence of antithyroid antibodies leading to hyperthyroidism. Pretibial myxoedema (localized oedematous and thickened pretibial plaque formation), thyroid acropachy (clubbing of the fingers and toes associated with soft-tissue swelling of hands and feet and with periosteal new bone formation) and exophthalmos are features of Graves’disease (collectively known as Diamond’s triad).
  4. Sjögren's Syndrome (Mikulicz Disease, Sicca Syndrome):
    Sjögren's syndrome is an autoimmune disorder that affects primarily secretory glands, in particular the lacrimal and salivary glands. The classic triad consists of keratoconjunctivitis sicca, xerostomia and arthritis. Cutaneous manifestations include xerosis, petechiae, purpura (palpable and non-palpable), urticarial vasculitis and annular erythema.
  5. Graham Little–Piccardi–Lassueur Syndrome:
    It is a variant of lichen planopilaris characterised by the triad of multifocal scalp cicatricial alopecia, non -cicatricial loss of pubic and axillary hairs, and keratotic lichenoid follicular papules.
  6. Wegener’s Granulomatosis:
    It is classically described as a triad consisting of systemic small vessel vasculitis, necrotizing granulomatous inflammation of both the upper and lower respiratory tracts, and pauci immune glomerulonephritis.
  7. Hyper-Ige Syndrome:
    It is characterised by classic triad of recurrent cutaneous and sinopulmonary infections, chronic eczematoid dermatitis and elevated serum IgE (usually in the range of 2000–40 000 U/l).
  8. Churg–Strauss Syndrome:
    It is characterised by triad of asthma, peripheral blood eosinophilia and necrotizing granulomatous vasculitis that involves small to medium-sized vessels.
  9. Still's Disease:
    Systemic-onset juvenile idiopathic arthritis, also known as Still's disease, is characterized by triad of high spiking fevers, arthritis and an urticarial eruption (transient cutaneous eruptions of erythematous macules and papules).
  10. Metabolic:
    1. Pellagra:
      It represents the classic form of vitamin B3 (niacin) deficiency characterised by classical triad of clinical features dermatitis, diarrhoea and dementia. The dermatitis begins as symmetric erythema in sun-exposed areas that later become scarlet or hyperpigmented with desquamation and crusting. On the face, a symmetrical ‘butterfly’ eruption is frequently observed and there is often a characteristic well-marginated eruption on the front of the neck (‘Casal’s necklace’). In addition to diarrhoea, abdominal pain and achlorhydria may be present. Dementia develops in the setting of prolonged niacin deficiency; patients are depressed, apathetic, irritable, anxious and, in severe instances, have frank disorientation.
    2. Hair-An syndrome:
      It is the triad of hyperandrogenism, insulin resistance and acanthosis nigricans in women.
  11. Primary Systemic Amyloidosis:
    1. It is a condition characterised by abnormal extracellular deposition of amyloid (AL) in tissues associated with plasma cell dyscrasia or multiple myeloma. The diagnosis should always be considered when a patient presents with the triad of carpal tunnel syndrome, macroglossia and mucocutaneous skin lesions (waxy nodules and plaques, ecchymoses, pinch purpura).
    2. Scleromyxedema:
    3. It is a chronic idiopathic disorder characterized by numerous firm waxy papules and areas of induration that are due to microscopic triad of increased dermal mucin, an increase in dermal collagen deposition and marked fibroblast proliferation.
  12. Pancreatic Panniculitis (Schmid's Triad):
    In pancreatic panniculitis, erythematous, edematous subcutaneous nodules develop, most often on the legs but also on the abdomen, chest, arms and scalp. Its association with polyarthritis and eosinophilia is known as Schmid's triad, and is associated with a poor prognosis.

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