Coupon Accepted Successfully!


Open Flashcards


3 out of 12

True about Raynaud's disease are all except: (AIPG 06)

A More common in females

B Good prognosis

C ANA is negative

D Scleroderma causes Raynaud’s phenomenon

Ans. C ANA is negative (Ref. H- Pg-2097)

Definition-This is a generalised disorder of connective tissue characterised by fibrosis and degenerative changes in the skin (scleroderma) and many internal organs.

Etiopathogenesis- Due to immunologically determined inflammation causing intimal thickening of small blood vessels leading to impaired microcirculation in the all body organs.

Age: F>>M , 30 – 50 Yrs

1. Skin Changes

i. Non – pitting oedema and induration associated with ‘sausage’ swelling and restriction of movement of the fingers.

ii. Sclerodactyly is a localized thickening and tightness of the skin of the fingers or toes.

iii. Skin becomes shiny with atrophy and ulceration of the finger tips with or without associated calcinosis.

iv. Hyperpigmentation and telangiectasis become taut and ‘mask – like’ with ‘beaking’ of the nose and difficulty in opening the mouth (microstomia).

v. Thickening of skin is the most easily recognizable manifestation of scleroderma.

vi. Early in the course of diffuse scleroderma, the skin appears edematous and inflamed with erythema and pigmentary changes. Hyperpigmented areas of skin due to deposition of melanin alternate with vitiligo like areas of depigmentation, this imparts the skin a salt and pepper appearance.

Patients scleroderma are typically classified based on the amount and location of skin involvement.

1. Diffuse scleroderma

i. Widespread skin involvement

ii. Rapid progression and early visceral involvement

2. Limited scleroderma

i. Limited skin involvement, confined to fingers, forearms

ii. When skin alone is involved then it is known as Morphea. (AIPG 2006)

CREST syndrome which is a combination of

1. Calcinosis: subcutaneous calcifications of fingers and along extensor surface of forearm

2. Raynaud phenomenon

3. Esophageal dysmotility

4. Sclerodactyly (skin thickening limited to fingers)

5. Telangiectasia (dilated capillaries)

Rheumatology Flashcard List

12 flashcards