True about metastatic calcification – (AIIMS May 2012)
|A||Serum ca level is normal|
|B||Occurs in dead/dying tissue|
|C||Occurs in damaged heart valves|
|D||Calcification starts in mitochondria|
The fundamental abnormality is the pathological entry of large amount of ionic calcium into the cell organelle, chiefly the mitochondria (it is suggested that mitochondria are the organelles first involved in the pathogenesis of metastatic calcification).