True about prion is?
|A||Are virus coded|
|B||Cause misfolding of proteins|
|D||Defect in folding of protein|
a. Prion disease are neuro degenerative disorders due to transmission of unique proteinaceous particles lacking RNA or DNA which are pathogenic isoforms of a prion protein normally present in the neuronal cell membrane
b. Normal prion protein is protease sensitive, soluble, rich in alpha helices-PRPsen
c. Direct exposure to an abnormal form (protease resistant, insoluble, beta sheets) causes the misfolding of the normal protein.