True in Menetrier's disease are except:
|A||Rugal fold hypertrophy|
|C||Protein losing gastropathy|
Hypertrophic Gastropathy (Ménétrier's Disease)
b. The latter is characteristically associated with protein-losing gastropathy and hypochlorhydria.
c. There is a hyperplastic hypersecretory variant of Ménétrier's disease characterized by normal or increased acid secretion and no protein loss.
d. There are large rugal folds in the proximal stomach, and the antrum is usually spared.
e. Mucosal biopsy shows diffuse hyperplasia of the surface mucus-secreting cells .
f. The etiology is unclear, and there may be an increased risk of gastric cancer.
g. Most patients with Ménétrier's disease are middle-aged men who present with epigastric pain, weight loss, diarrhea, and hypoproteinemia.
h. Sometimes the disease regresses spontaneously.
i. Gastric resection may be indicated for bleeding, severe hypoproteinemia, or cancer in some patients with this rare problem.