Valproate causes all except
a. Osteomalacia is not a side effect of sodium valproate. However, phenytoin on the other hand can cause this problem. Sodium valproate is a carboxylic acid derivative that has a simple chemical structure of any antiepileptic drug.
b. The drug acts by stimulating the GABA release and this causes increase in seizure threshold. It is most effective antiepileptic drug and is well absorbed orally.
c. The drug has reasonably good oral bioavailability and is metabolized by non-cytochromal enzyme. The drug has short half life.
d. Most common side effect is gastrointestinal upset. Other side effects include weight gain, tremors, fulminant hepatitis and polycystyic ovarian disease.
e. The last side effect has been described recently. The drug should not be given along with clonazepam as it may precipitate status absence (BG Katzung’ 10th Edition, pp-386-88).
(Remember: Long term side effect of Valproate is: weight gain and reversible hair loss)