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5 out of 6

Which of the following is the mechanism of action of Pentasaccharide? (PNQ)

A Factor Xa inhibition, Thrombin inhibition

B Factor Xa inhibition

C Antithrombin inhibitor

D Thrombin inhibition

Ans. B

Factor Xa inhibition


Mechanism of action: Factor Xa inhibition Example: Fondaparinux, Idraparinux

Extra Edge: Newer factor Xa inhibitor:

1. Rivaroxaban

2. Apixaban (Ref. Hari-18th ed., Pg.-1000) Both are given orally.

Extra Edge: Dabigatran, an oral thrombin inhibitor, Rivaroxaban & Apixaban both are oral Factor Xa inhibitor, are used for short-term thrombo prophylaxis after elective hip or knee replacement surgery.

Dabigatran is used as an alternative to warfarin for stroke prevention in patients with atrial fibrillation. (Harrison 18th, ed., page-992)