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7 out of 10

Which of the following is the site of estrogen action:

A Mitochondria
B Cell membrane

C Nucleus
D Cytoplasmic receptors

Ans. C Nucleus
  1. Hormonal steroids and thyroid hormones exert their main physiological effects by acting directly on the NUCLEI their target cells to increase transcription of selected mRNAs.
  2. Like other steroids estrogen combines with an intracellular protein receptor and this complex binds to DNA.
  3. This promotes formation of mRNAs which in turn direct the formation of new proteins which modify the cell function.