Which of the following is not decreased in diabetes mellitus
|B||Acetyl CoA carboxylase|
In starvation and Diabetes Mellitus (i.e. Insulin Deficiency and excess of Glucagon): -
a. Activity of Enzymes of Glycogenesis, glycolysis and pyruvate oxidation, - are decreased eg. glycogen
synthase, Glucokinase, phosphofructokinase- 1, pyruvate kinase, pyruvate deHase,
b. Activity of enzymes of Gluconeogenesis are increased eg. Pyruvate carboxylase phosphoenol pyruvate carboxykinase, Fructose-i, 6-bisphosphatase, Glucose-6, phosphatase.
c. Activity of Pentose-phosphate-pathway enzymes and Lipogenesis enzymes: - are decreased eg. Glu-6-phosphate deHase, 6-phosphogluconate deHase, Malic enzyme, ATP-citrate Lyase, Acetyl CoA —
carboxylase, Fatty acid synthase