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Central Nervous System

1 out of 5

Which of the following exclusively involve neurons (AIIMS NOV.2011)

A Supra nuclear palsy

B Spinocerebellar ataxia

C Corticobasilar degeneration

D Multiple system atrophy

Ans. B Spinocerebellar ataxia

a. Spinocerebellar ataxia : It involves only the neurons whereas in other lesion cells like glial cells etc can also be involved.

b. Corticobasilar degeneration
Corticobasilar degeneration is a rare condition that causes symptoms like PSP but can be unilateral (affecting only one side of the body) and eye movement may not be affected. Cortico-basilar degeneration: severe cell loss in the pre- and post-central parietal area. Symptoms include stiffness, ataxia, choreiform movements, flexion dystonia, vertical gaze palsy, parkinsonian features and cerebellar and pyramidal tract signs.

c. Steele-Richardson-Olszewski syndrome or progressive supranuclear palsy (PSP): first described in the 1960s, this symmetrical disease is characterised by rigidity, falls (backward), a fixed facial expression, inability to look down and speech and swallowing problems. Tremor is rare and then only during movement.

d. Multiple system atrophy Multiple system atrophy (MSA) is a rare condition that causes symptoms similar to Parkinson's disease. However, patients with MSA have more widespread damage to the part of the nervous system that controls important functions such as heart rate, blood pressure, and sweating.