Which of the following can be given with dose adjustment: (AIIME Nov 2011)
|A||Levodopa + metoclopramide|
|B||Gentamicin + Furosemide|
|C||Ferrous sulphate + Tetracycline|
|D||Clonidine + Chlorpromazine|
a. Tetracyclines have chelating property forms insoluble and unabsorbable complexes with calcium and other metals. Milk, iron preparations, nonsystemic antacids and sucralfate reduce their absorption.
b. Administration of these substances and tetracyclines should be staggered, if they cannot be avoided altogether. When combined with ferrous sulphate, it does not have any adverse interaction; the combination can be safely prescribed with dose adjustment.
c. Now looking at the other options:
About clonidine + chlorpromazine
Chlorpromazine abolishes the antihypertensive action of clonidine probably by blocking the alpha receptors on which it acts.
About Gentamicin + Furosemide
High ceiling diuretics (Furosemide) and Aminoglycoside antibiotics are both ototoxic, produce additive toxicity and should not be used together.
Levodopa and Metoclopramide
Metoclopramide reverse the therapeutic effect of Levodopa by blocking DA receptors