7 out of 42
Which of the following helps in bridging the fibrin in a clot and stabilizing the clot? (AIPG 2008)
Ans. D Factor XIII Explanation :-
- The fundamental reaction in the clotting of blood is conversion of the soluble plasma protein fibrinogen to insoluble fibrin.
- The process involves the release of two pairs of polypeptides from each fibrinogen molecule.
- The remaining portion, fibrin monomer then polymerizes with other monomer molecules to form fibrin.
- The fibrin is initially a loose mesh of interlacing strands.
- It is converted by the formation of covalent cross-linkages to a dense, tight aggregate (stabilization ).
- This latter reaction is catalyzed by activated factor XIII and requires Ca 2+ .