Which of the following precautions is advisable when using lovastatin? (AIIMS Nov 2012)
|A||Serum transaminase measurements|
|B||Renal function studies|
|D||Monthly complete blood counts|
a. Lovastatin should not be used in patients with severe liver disease. With routine use of lovastatin, serum transaminase values may rise, and in such patients, the drug may be continued only with great caution.
b. Lovastatin has also been associated with lenticular opacities, and slit-lamp studies should be done before and 1 year after the start of therapy.
c. The drug is not toxic to the renal system.
d. There is a small incidence of myopathy, and levels of creatinine kinase should be measured when unexplained muscle pain occurs.
e. Combination with cyclosporine or clofibrate has led to myopathy. There is no danger in use with bile acid sequestrants.