Which of the following statement is true regarding adjuvants?
|A||Adjuvants decrease the efficacy of vaccines|
|B||More antigens are needed when an adjuvant is added.|
|C||More antibodies are produced when an adjuvant is added|
|D||More doses are needed when an adjuvant is added|
a. The immune response to some antigens is potentiated by the addition of adjuvants such as aluminum salts or, in the case of polysaccharides (e.g., the polyribose phosphate oligosaccharide of Hib), by conjugation to a carrier protein.
b. Adjuvants, nonspecific boosters of immune responses, are used with inactivated products such as diphtheria and tetanus toxoids, acellular pertussis (aP) vaccine, and HBV vaccine.
c. The mechanism for adjuvant enhancement of immunogenicity is not well defined but relates in part to the rendering of soluble antigens into a particulate form, the mobilization of phagocytes to the site of antigen deposition, and the slowing down of the release of antigens, which prolongs stimulation of the immune response.
d. Adjuvants increase the efficacy of vaccines
e. Less antigens are needed when an adjuvant is added
f. More antibodies are produced when an adjuvant is added
g. Less doses are needed when an adjuvant is added