Which one of the following statement regarding to desflurane is correct:
|A||Causes severe myocardial depression|
|B||It is structural analogue of isoflurane|
|C||It has high blood and tissue gas partition coefficient|
|D||It is metabolically unstable|
It is structural analogue of isoflurane
a. Desflurane is structural analogue of isoflurane. It has lowest blood/tissue coefficient, so has fastest induction and recovery. It is metabolically stable (only < 1 % is metabolized).
b. It does not depress myocardium, rather may increase cardiac output by stimulating sympathetic system at concentration> 1 MAC (6%).