31 out of 100
Which one of the following anti-cancerous drug is a Peptide? (LQ)
Ans. C Bleomycin
- This is a mixture of closely related glycopeptide antibiotics having potent antitumor activity.
- It chelates copper or iron, produces superoxide ions and intercalates between DNA strands– causes chain scission and inhibits repair.
- It is highly effective in testicular tumor and squamous cell carcinoma of skin, oral cavity, head and neck, genitourinary tract and esophagus; also useful in Hodkgin’s lymphoma.
- Mucocutaneous toxicity and pulmonary fibrosis, but little myelosuppression are the special features.