Which one of the following is not associated with adult polycystic kidney disease? (AIIMS May 2013)
|A||Autosomal dominant inheritance|
|B||Mutations involving gene affecting interactions|
|C||Intracranial berry aneurysm may be|
|D||Tricuspid valve prolapsed|
Mitral valve prolapse (and not tricuspid valve prolapse) and other cardiac valvular anomalies occur in 20% to 25% of patients.
Adult polycystic kidney disease (APKD) is a hereditary disorder characterized by multiple expanding cysts of both kidneys that ultimately destroy the renal parenchyma and cause renal failure. It is an autosomal dominant condition caused by mutation in PKD1 gene encoding for polycystin-1. This protein is present on distal tubular epithelial cells. It is involved in cell-cell and cell-matrix interactions. The PKD2 gene product polycystirt-2 is localized to all segments of the renal tubules and may act as a Ca2*-permeable cation channel for regulatoring intracellular Ca2* levels.