Which part of the brain is responsible for narcolepsy (NEET 2013)
Narcolepsy and were found to have a defect in one of the receptors for orexins ( Ref. Hariypocretins) in the hypothalamus. (Ref. Ganong 22nd ed. Page no. 201)
Narcolepsy and Cataplexy
1). Narcolepsy (sudden irresistible urge to sleep) cataplexy (sudden loss of muscle tone following strong emotional disturbance) HLA DR-2 is characteristic ( Ref. Hari-18th ed., pg 220)
2). REM sleep occurs within 15 min of onset of sleep in narcolepsy.
3). Treatment of narcolepsy: ( Ref. Hari-18th ed., pg 220)
a. Modafinil is the drug of choice
b. Older drugs such as methylphenidate or dextroamphetamine are still used as alternatives.
4). Treatment of the REM-related phenomena of cataplexy, hypnagogic hallucinations, and sleep paralysis requires the potent REM sleep suppression produced by antidepressant medications.
a. The tricyclic antidepressants [Protriptyline and Clomipramine]
b. SSRIs (Fluoxetine)
Armodafinil is approved by the FDA for the treatment of narcolepsy and as an adjunctive treatment for obstructive sleep apnea.