amplitude of action potential can be increased maximally by
|A||decreased absolute refractory period|
|B||increased no. of open Na+ channel|
|C||increased no. of open K+ channel|
|D||increased frequency of opening of Na+ channel|
a. Na+ is critical for the action potential in nerve cells. Action potentials are repeatedly initiated as the extracellular concentration of Na+ is modified.
b. As the concentration of sodium in the extracellular solution is reduced, the action potentials become smaller. Same is observed when we block sodium channels.
c. K+ channels are responsible for repolarisation, so they will rather decrease the amplitude of AP, infact if only sodium channels were there in open state not K+, amplitude would reach close to equilibrium potential of sodium i.e. +60 mV.
d. The absolute refractory period is a period of time after the initiation of one action potential when it is impossible to initiate a second action potential no matter how much the cell is depolarized. So, it is not a major factor for amplitude since no AP would occur here and if we shorten it and get 2nd AP , its amplitude is always less than the first one.