The immune response is also called the specific defense system because it is a reaction to a particular type of pathogen and is effective only against that pathogen. The immune response is only activated if a pathogen breaches the non-specific defenses and enters the circulation, creating a systemic infection. Two types of lymphocytes are involved in the immune response: T lymphocytes (or T cells) and B lymphocytes (or B cells). Both are produced by the bone marrow. B cells remain and mature in the marrow, while the T cells migrate to the thymus to continue their maturation. Both cell types eventually move to the lymphatic system and collect in the lymph nodes and spleen (some lymphocytes also circulate in the blood). While both types of lymphocytes are part of the immune response, they approach their respective tasks in different ways.
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